![]() ![]() Two other mineralocorticoids in man, cortisol and 11 deoxycorticosterone (DOC), at the zona fasciculata, will not escape the long-term effect of chronic ACTH excess and their secretion rates will remain elevated in parallel. Chronic ACTH excess leads to chronic adrenal mineralocorticoid excess and low aldosterone levels: after an acute rise, aldosterone plasma levels resume low values after a few days when ACTH is prolonged. ![]() Excess adrenal androgens also occur: in females, they will overcompensate the gonadotrophic loss, inducing high testosterone in males, they will not compensate it, inducing low testosterone. ![]() Service des Maladies Endocriniennes et Métaboliques, Centre de Référence des Maladies Rares de la Surrénale, Faculté de Médecine Paris Descartes, Université Paris 5, Hôpital Cochin, Paris, FranceĬhronic ACTH excess leads to chronic cortisol excess, without escape phenomenon, resulting in Cushing’s syndrome.
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